Cohort Information
GEFOS
GEFOS - Cohorts View Larger Map
The Rotterdam Study is a population-based, prospective cohort study of unrelated men and women aged
55 years and over, initiated to asses prevalence, incidence, and determinants of diseases in the eldery.
Participating investigators: André Uitterlinden, Fernando Rivadeneira, Karol Estrada, Ling Oei,
Huib Pols,
Hans van Leeuwen, Joyce van Meurs, Lisette Stolk.
The TwinsUK cohort was setup in 1992 and consists predominantly of 10.000 females and 1000 males identical
and non-identical twins in equal proportions aged 18-85, with mean age of 50 recruited by media campaigns
and found to be representative of the UK Caucasian general population.
Participating investigators: Brent Richards.
Within the European Prospective Investigation of Cancer (EPIC), a 250.000 subject Europe-wide EU funded
study into the dietary determinants of cancer, EPIC-Norfolk recruited nearly 25,000 men and women aged
45-74 years in Norfolk, UK.
The Framingham Osteoporosis Study is an ancillary study of the Framingham Heart Study, a large, longitudinal
population- and family-based study funded by the National Institute of Heart, Lung and Blood Diseases that
began in 1948.
The SOF study is co-funded by the National Institute of Aging and the National Institute of Arthritis and
Musculoskeletal and Skin diseases, is a longitudinal epidemiologic study of 9,704 women aged 65-99 years
(mean 71.7, SD 5.3) and older recruited from four study centres located in Portland, OR; Baltimore, MD;
Minneapolis, MN; and the Monongahela Valley near Pittsburgh, PA.
The Australian samples with GWA data are being recruited from ongoing prospective population based
osteoporosis studies: the Dubbo Osteoporosis Epidemiology Study (DOES), the Geelong Osteoporosis Study
(GOS), Calcium Intake Fracture Outcome Study (CAIFOS), Tasmanian Older Adult Cohort (TASOAC), and the
Austin Hospital cohort.
The Erasmus Rucphen Family (ERF) study is and extended-pedigree study (n=2700) focused on the identification
of quantative traits loci related to neuropsychiatric, cardiovascular, endocrinologic, ophthalmologic and
musculoskeletal disorders.
The deCODE GWA study population is derived from three sources: BMD measurements (DXA-Hologic) from everyone
that have had BMD measurements in Iceland and has participated in any of deCODEs disease/trait study programs,
femoral neck fracture patients recruited based on hospital records for a femoral neck fracture surgery, and
controls whom are not phenotyped of OP.
The Croatia genetic isolate study represents collaboration between the University of Edinburgh, the MRC
Human Genetics Unit, and the Universities of Split and Zagreb. The study is based on the villages of Komiza
and Vis on the island of Vis in the Adriatic.
