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Introduction
GEFOS stands for the GEnetic Factors for OSteoporosis Consortium. It is a large international collaboration involving various prominent research groups.
Osteoporosis is a common age-related complex disease with a strong genetic component. Osteoporotic
fractures account for considerable disease burden and costs.
The genes responsible, however, are poorly defined. It is by now generally assumed that - like for
many other complex diseases such as diabetes and cardiovascular disease - many gene variants are
responsible but each with subtle effect.
In a previous EU FP5 funded project, named GENOMOS, we have improved on this situation by bringing
together several of Europe's largest collections of osteoporosic study populations with DNA available,
and analysing the most commonly studied.
With the GEFOS project we here propose to capitalize on the success of GENOMOS by using the most advanced
gene discovery tools that have become recently available, i.e., Genome Wide Association (GWA) analysis
with high density SNP arrays, to identify common risk gene variants for osteoporosis.
GEFOS is a European Union Seventh Framework Package funded project, registered under grant agreement number: FP7-HEALTH- F2-2008-201865-GEFOS
News
10th GEFOS/ 20th GENOMOS Investigators meeting Stockholm(2012-05-04)
IMPORTANT UPDATED DATE!!!!
The GEFOS/GENOMOS meeting will take place on SUNDAY May 20th 6:00-9:00 PM CET, co-organised by Dr. Liesbeth van den Put and the GEFOS Coordinating Center Rotterdam. Sandwiches and beverages will be served.
Venue: First Hotel Royal Star (http://www.firsthotels.com/Our-hotels/Hotels-in-Sweden/Stockholm/First-Hotel-RoyalStar/) > (adjacent to the convention center)
NEW BMD LOCI ASSOCIATED WITH FRACTURE(2012-04-16)
In the latest effort of the
GEFOS/GENOMOS consortia we have identified
56 BMD loci of which
14 are significantly associated with
fracture risk. These large collaborative effort include 17 GWAS and 34 GENOMOS studies worldwide constituting the largest study of its kind ever done.
The results are published online in the
Nature Genetics journal.
Download the press release for more information or go to the
Nature Genetics website.
8th GEFOS / 18th GENOMOS Investigators meeting(2011-03-15)
The European Calcified Tissue Society (ECTS): May 7 - 11, 2011
Place: To be informed (near the ECTS Conference Center)
Date: May 7th, from 12:00 - 2:00 PM.
Lunch will be served.
Info: 7th GEFOS / 17th GENOMOS Investigators meeting.(2010-10-19)
7th GEFOS / 17th GENOMOS Investigators meeting.
The American Society for Bone and Mineral Research (ASBMR): October 15 - 19, 2010
Place: Queens Quay room, Westin Harbour Castle, Toronto, ONTARIO (near the ASBMR Conference Center)
Date: October 19th, from 1:00 - 5:00 PM.
Address: One Harbour Square * Toronto, ON * CANADA * M5J 1A6
Lunch will be served.
ASBMR Oral platform Presentation for GEFOS Efforts(2010-09-18)
The upcoming ASBMR meeting in Toronto will include several GEFOS efforts presented as platform orals including : 1.BMD GWAS Meta-analysis - Presentation Time: 10/18/2010 5:00:00 PM - 10/18/2010 5:15:00 PM
New working group on pQCT(2010-08-26)
pQCT GWA meta-analyses working group is now active!!! Go to the "Meetings Section" for further information
GEFOS findings in Endocrine Reviews(2010-04-29)
Replication genotyping GENOMOS studies(2010-02-12)
The second GEFOS meta-analysis on femoral neck and lumbar spine BMD including ~ 30,000 samples with genome-wide data is close to finalizing. De-novo genotyping in ~ 50,000 samples for about 50 SNPs from the BMD meta-analysis (and possibly other currently analyzed traits) will be pursued. This initiative is funded by the GEFOS FP7 EU Grant. Investiagtors interested in joining this effort please contact gefos[DOT]inw[AT]erasmusmc[DOT]nl. More information to come shortly.
59th ASHG Meeting(2009-10-24)
GEFOS findings in Annals of Internal medicine(2009-10-20)
Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture.
Link to Ann Int Medicine GEFOS findings in Nature Genetics (advance online publication)(2009-10-06)
