Data Release 2018

UK Biobank eBMD and Fracture GWAS Data Release 2018

The GEnetic Factors for OSteoporosis (GEFOS) Consortium is a large international collaboration comprising numerous research groups. Osteoporosis is a common age-related complex disease with a strong genetic component. The UK Biobank is a health resource from the United Kingdom that has genetic data and phenotype measurements in 500,000 individuals, representative of the general population. We analyzed the full batch of genetic data, including genotyping and imputed data in up to 426,824 participants. We performed genome-wide association studies on bone mineral density estimated from quantitative heel ultrasounds (eBMD) and from bone fractures.


This release comprises the summary data from our 2018 GWAS of eBMD and fracture in the full batch of genetic data from the UK Biobank. Analyses were performed based on the HRC imputation panel (hg19) including ~14,000,000 SNPs with MAF ≥ 0.05% and acceptable imputation quality (info score > 0.3).

Data file description

Each file contains the following information:

Descriptive ID for each SNP rs ID for each SNP Chromosome Position (hg19) Effect allele Non-effect allele Effect allele frequency Imputation quality score Effect estimate Standard error of the effect estimate P-value P-value from infinitesimal model (recommended for fracture data) P-value from non-infinitesimal model (recommended for eBMD data) Sample size


Morris, Kemp, et al. An atlas of genetic influences on osteoporosis in humans and mice. Nature Genetics 2018.

Terms of Use

We require appropriate attribution for use of data in a product, service, or publication by citing the article generating this set of results (Morris et al., Nature Genetics 2018) and acknowledging its use.


By downloading the files below, you explicitly agree to the Terms of Use stipulated above.